Can homeopathy aid in Alzheimer’s Disease. This review will focus on the effects of administering phosphatidylinositol, phosphatidylserine or phosphatidylcholine on unipolar depression by reviewing current human trials and animal data. Find out the health benefits and correct daily dosage. A Cochrane systematic review (Taylor 2004) combined all of the three studies and included a study that recruited only bipolar patients and found that even with a combined sample (n=141), the effect of inositol on depression scores is still not significant. However, I was told to take it in the early evening, around 6 p.m., to lower my evening cortisol levels so I would find it easier to rest in the evening. All four studies demonstrated a significant antidepressant effect from administration of inositol relative to placebo (Einat 1999, Einat 2002, Kofman 1993, Kofman 1998). For your privacy, only your first name (from your account) followed by a random number will appear with your comment. This inclusion of patients with bipolar makes it difficult to conclude whether inositol is effective in reducing depression in patients with unipolar depression. Nature. A total of three human trials were identified investigating the effects of inositol administration on depression. Q: Dr. Sherry Rogers prescribed Phosphatidylcholine for both my husband and me in the early 1990s. One study was identified examining endpoints relating to depression following administration of phosphatidylserine in rats. 1999;15(10):778-783. How are these supplements different? 1995;152(5):792-794. 2002;15(3):148-51. The effect of peripheral inositol injection on rat motor activity models of depression. 1995;36(1-2):51-56. Find out which supplements help improve memory, brain function and cognition, including fish oil, some B vitamins, cocoa, and curcumin. Reduced Myo-Inositol levels in cerebrospinal fluid from patients with affective disorder. Taylor MJ, Wilder H, Bhagwagar Z, Geddes J. Inositol for depressive disorders. 1999;106(7-8):795-8. Murray C, Lopez A. 50% of patients who responded to inositol in the initial trial had experienced a relapse in depressive symptoms after discontinuing treatment and no patients in the placebo arm who initially reported benefit experienced a relapse in symptoms. We stopped taking it for a while, due at least in part, to financial reasons. Diagnostic and statistical manual of mental disorders (4th ed., text rev.). Chronic dietary inositol enhances locomotor activity and brain inositol levels in rats. Effects were measured based on HDRS and a significant improvement was seen after 30 days in the treatment group when compared to controls (Brambilla 1998). It mainly increases the levels of Acetylcholine in the brain thus, improving memory and communication between neurons. Join now to save favorites and get all member benefits, including over 1,300 reviews. The conclusion was that administering inositol to depressed patients increases their CSF inositol levels significantly (Levine 1993); the findings inspired the first randomized clinical trial done by Levine and colleagues in 1995. DOI: 10.1002/14651858.CD004049.pub2. Another chemical form of choline sold in supplements has shown some promise in improving memory and cognition as explained in the Choline Supplements Review (which includes our tests and … Levine (1995) included 4 patients with bipolar depression in the inositol group (N=9). Inositol phosphates and cell signalling. Levine and colleagues (1999) administered inositol and standard SSRI treatment in the experimental group and used placebo with SSRIs as a control. If you make a statement of fact, such as whether a type of treatment does or does not work, state your basis -- such as personal experience or a published study. Acta Psychiatr Scand. The following may prove useful. Interest in administering phospholipids for treatment of MDD stems from animal and human data demonstrating that certain areas of the brain, plasma and CSF can show deficiencies in phospholipids in depressed patients. Israel Journal of Medical Sciences. Combination of inositol and serotonin reuptake inhibitors in the treatment of depression. Source: Phosphatidylcholine products that come from plants, all have two or more than two different types of phospholipids where there is a competing interest between the phospholipids (Phosphatidylcholine, Phosphotidylinositol and phosphotidyletanolamine). The current findings indicate that administering inositol to rats creates a significant reduction in depressive symptoms as reported by several studies (Einat 2000, Einat 2002, Kofman 1998, Kofman 1993). In the case of moderate or severe depression, selective serotonin reuptake inhibitors (SSRIs) are used as the first line of treatment. The World Health Organization (WHO) in the 1990s ranked depression to be the fourth cause of global disease burden. Before deciding which supplement is better, it is important to compare their differences. 1998;139:239–242. All patients received the placebo for at least 7 days followed by a washout period before receiving 300mg/day of phosphatidylserine for 30 days. N Engl J Med. Ten females were recruited for this study, 8 with MDD and 2 with bipolar depression. The DSM-IV-RT defines depression as a mood disorder. In 2001, depression rose to be the third leading cause of Global Disease Burden (GDB) worldwide (Murray 1997). Citicoline, also known as CDP Choline, Cytidine diphosphate-choline, is a popular nootropic known to improve cognitive function and brain health.